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Shen and colleagues, in a 2019 study, showed that madecassoside, a major Centella compound, both calmed inflammatory signaling and improved skin hydration markers, including hyaluronan production by dermal fibroblasts, and a 2024 review of topical Centella in wound healing reinforces the collagen-synthesis and anti-inflammatory mechanisms

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Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation

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The applicant stated that VasQ TM would be reported with HCPCS codes as shown in Table 101, previously published as Table 50 of the CY 2026 OPPS/ASC proposed rule (90 FR 33581)