Semaglutide is a GLP-1 selective medication with strong evidence and a well-established safety profile
As for methylation, GNGT1, KCNS3, GCG and PPKACG tended to be hypomethylated in pan-cancer while ADCY8 tended to be hypermethylated (Figure 2D)
For participants with underlying health issues or prior exposure to incretin-based therapies, adjusting dosages may be necessary under the supervision of a healthcare provider
If we framed them correctly from the start - this medication restores metabolic function, which happens to result in weight loss for those carrying excess fat - the conversation would be different
doi:10.1210/endo.133.4.8404634
Individual results vary and depend on adherence, health profile, and the treatment plan prescribed