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House Dust Mite Induces Sonic Hedgehog Signaling That Mediates Epithelialmesenchymal Transition in Human Bronchial Epithelial Cells

The application of three advanced experimental techniques (proton-induced X-ray emission, Rutherford backscattering spectrometry, and ion microscopy) revealed an increased level of metals in the human tissues containing A plaques compared to surrounding tissues

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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

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