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End Stage Renal Disease (ESRD) patients on maintenance hemodialysis may have low plasma carnitine concentrations and an increased ratio of acylcarnitine/carnitine because of reduced intake of meat and dairy products, reduced renal synthesis and dialytic losses

The CR process regulates the immune and physiological function, and any disruption in it leads to severe diseases, including cardiovascular, neurodegenerative, cancer, etc

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doi: 10.1016/j.ajog.2012.02.016 223 HaasDMDantzerJLehmannASPhilipsSSkaarTCMcCormickCLet al