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OXIDATIVE STRESS, INSULIN SIGNALING AND DIABETES Hristov, B.D

Since IL-17 receptor A (IL-17RA) has been shown to mediate communication from the meninges to the cortex 47 , we next examined whether the beneficial effect of peripherally targeting CD38 could be mediated in part through modulation of cortical IL-17RA and IL-1 signaling, which we observed to drive T H 17 pathogenicity

The strongest association is found within the IDDM2 locus, which corresponds to the allelic variation at the INS variable number of tandem repeats (VNTR) (59)