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Specifically, ROS can modulate the activity of key enzymes in the glycolysis process through oxidation modification, such as hexokinase [171], phosphofructokinase-1 [172], and pyruvate kinase [173]

NRP1 structure/function NRPs are single-pass transmembrane, non-tyrosine kinase surface glycoproteins, expressed by endothelial, immune, and vascular smooth muscle cells and are regulators of numerous signaling pathways within the vasculature 313,314

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