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In fact, from a database of 186 mutant alleles that are now known, a reasonably clear pattern has emerged (see Table 18-2 )

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In addition to being potential Nrf2-activators, isothiocyanates also have Nrf2-independent properties, including inhibition of mitochondrial fission and the mTOR pathway

Jun 3 2021;10(6)doi:10.3390/antiox10060906 Lee BJ, Tseng YF, Yen CH, Lin PT

Activation of the caspase cascade system, such as caspase-3, caspase-8, caspase-9, and poly (ADP-ribose) polymerase, and the increased level of P53, ROS, and the ratio of Bax/Bcl-2 contribute to loss of MMP in epithelial cells (Table 2) (117)