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Mechanism of action Melanotan II acts as a non-selective agonist of the melanocortin receptors MC1, MC3, MC4, and MC5

This agent is selectively cytotoxic for abnormal melanocytes due to the reversible inhibition of tyrosinase and the inhibition of mitochondrial enzymes.136 It is applied twice a day for 2 to 12 weeks, depending on response.1 Treatment results have been highly variable,137139 and there is insufficient evidence to recommend its use over other modalities in clinical practice

For example, switch between the stomach, thighs, and upper arms

Mehta LS, Velarde GP, Lewey J, Sharma G, Bond RM, Navas-Acien A, et al

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The 2.5 mg dose is intentionally low to ease you into treatment while minimizing severe side effects