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The areas thus obtained for standard TMA were correlated with the area of the internal standard, and the resulting ratio (TMA/D9-TMA or TMAO/D9-TMAO) was correlated with the standard concentration to verify the range of linearity of the response, which was in the range from 25 nM to 100 M

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LDCT emphysema assessment was simultaneously performed by a pneumologist, general radiologist and thoracic radiologist, with emphysema being classified as minimal ( 50%)