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A later study confirmed these effects extend to both dopamine and serotonin turnover across multiple brain regions (Sikiri et al., Curr Pharm Des, 2010)

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The strongest data are around weight reduction and improvement in insulin resistance

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Subsequently, a urine sample was sent for organic acid analysis, which revealed a "large elevation" of pyroglutamate (5-oxoproline), thus confirming the diagnosis

2 Ocular findings have also been associated with the likelihood of developing PHN, including decreased corneal sensation, conjunctivitis, keratitis, and uveitis