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The passive paracellular route only allows the passage of molecules that are smaller than 500 Da

It is a dual GIP and GLP-1 receptor agonist, meaning it activates two incretin pathways simultaneously

doi: 10.1172/JCI105685 5 McintyreNHoldsworthCDTurnerDS

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Diabetes 64(10):34063412 Cukierman-Yaffe T, Gerstein HC, Colhoun HM et al (2020) Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

In particular, preclinical studies have demonstrated that GLP-1 and its more stable and long-lasting analogues GLP-1RAs possess neuroprotective and antiapoptotic properties, modulate long-term potentiation and synaptic plasticity, as well as promote the differentiation of neuron precursors, and can reduce depressive behavior [75]