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These beneficial effects were linked to enhanced formation of filamentous actin (F-actin) and activation of key cytoskeletal signaling pathways, including focal adhesion kinase (FAK) and paxillin

The titration schedule exists for a reason, and the full effect often isn't apparent until you've been at a therapeutic dose for several weeks

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Tisserand DJ, Pruessner JC, Arigita EJS, van Boxtel MPJ, Evans AC, Jolles J et al (2002)

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