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The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, Tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes

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10.1074/jbc.M114.563031 J

These immunomodulatory effects were abolished in mice lacking GLP-1R in the Cdh5 domain, which targets the endothelial lineage, but remained intact in myeloid-targeting Glp1r Lyz2/ mice

Lipid based nanoparticle technologies for liver targeting