acetaminophen glutathione autism Tylenol and Autism: Why the Science Is More Nuanced Than Headlines The impact of glutathione metabolism

10.1534/genetics.167.1.1 48 InusaB

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found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells