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Most could remain in the trial, but a handful dropped out prematurely because of severe side effects or weight loss

The compounded tirzepatide with B12 approach adds energy support and helps address B12 deficiency that some patients experience during caloric restriction

Contraindications and special populations require attention

Patients with a personal or family history of medullary thyroid carcinoma should not use GLP-1 agents

Probiotics: Your Guts Besties Your gut microbiome is like a bustling metropolis of microorganisms, and when the right residents are thriving, they produce compounds that directly stimulate GLP-1 release

It may be necessary to attack each of these likely causes with separate drug development programs