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Staining was completed by incubating sections for 1 to 3 minutes with 3,3-0-diaminobenzidine substrate-chromogen, which results in a brown-colored precipitate at the antigen site

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Brandeis D, Lehmann D, Michel CM, Mingrone W (1995)

Long-term safety studies, however, have not been conducted (see Concerns and Cautions)

Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

GSH is a physiological substrate of ABCC1