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Understanding GLP-1 dosing: Starting low and titrating up All GLP-1 medications (glucagon-like peptide-1 receptor agonists) are initiated at a low dose and their dosage is gradually escalated over time to enhance your bodys tolerability and minimize the risk of side effects, particularly gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation

N Engl J Med 383, 1436-1446 (2020)

They may adjust your dosage or recommend strategies to manage nausea

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This disconnect confuses newcomers who assume more peptide equals better results

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