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Proc Natl Acad Sci U S A (2000) 97(12):68749.10.1073/pnas.120069197 55 ConarelloSLLiZRonanJRoyRSZhuLJiangGet alMice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

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One explanation is that TGR5 activates thyroid hormones in brown adipose tissue and muscle cells by stimulating type II iodothyronine deiodinase (DIO2) [103]

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