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Due to morbid obesity, individuals with PWS may experience numerous complications, such as type 2 diabetes mellitus (T2DM), metabolic syndrome, obstructive sleep apnea, respiratory failure, thromboembolism, pulmonary hypertension, and right heart failure

These participants received orforglipron 3 mg ( N = 47), 12 mg ( N = 50), 24 mg ( N = 42), 36 mg ( N = 59), 45 mg ( N = 59), dulaglutide 1.5 mg ( N = 50), or placebo ( N = 54)

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Chronic administration of melatonin: physiological and clinical considerations