Attaching a 16-carbon side chain (palmitic acid) to the peptide allowed the molecule to bind to the abundant blood protein albumin and keep it in circulation
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Thereafter, DARPP is converted into 5-amino-6-ribityl-amino-2,4(1H,3H)pyrimidinedione (ArP) by sequential reactions of deamination, side chain reduction, and dephosphorylation (Figure 1)
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