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evaluated 60 healthy professionals aged 35 to 55 who took 150 mg of Pycnogenol daily for 12 weeks

Antioxidant Support : Glutathione and vitamin C can help defend cells against daily stressors

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Glycine and serine (serine is converted to glycine for GSH synthesis) are spent making GSH, but glutamate is increased once GSH exits the cell and is transaminated by GGT, releasing glutamate into circulation

It acts as a mitochondrial messenger that communicates with the nucleus to maintain cellular homeostasis, making it a promising target for research on metabolic health, exercise performance, and healthy aging 1-4

Therefore, therapies targeting only cartilage or synovium may be insufficient