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Having confirmed that semaglutide altered alcohols interoceptive effects, we next assessed whether this effect generalized to acute treatment with tirzepatide and retatrutide in Experiments 3 and 4

Many endocrinologists now prescribe semaglutide or tirzepatide before considering insulin therapy

Patients are randomized in parallel fashion to subcutaneous tirzepatide once weekly or matching placebo

Responses to medications can differ greatly based on factors such as metabolic characteristics, tolerability, lifestyle, and personal preferences

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Prioritizing sleep, staying hydrated, and eating adequate protein helps energy recover more quickly