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As a common opportunistic pathogen, Staphylococcus aureus produces toxins and enzymes that induce tissue damage and inflammatory responses ( Escherichia coli , Klebsiella pneumoniae , Acinetobacter baumannii , and Pseudomonas aeruginosa are key pathogens ( Cryptococcus , Aspergillus , and Pneumocystis jirovecii ( In fact, pulmonary infections including bacterial infections, fungal infections, and viral infections are all associated with dysbiosis of the lung microbiota