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Table 4 Different marketed polyherbal drugs with their composition and mechanism of action as dipeptidyl peptidase-IV inhibitors

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In addition to altering food satiety signals, GLP-1 is suggested to modulate satiety in drugs of abuse and alter reward-related changes in multiple drugs of abuse such as cocaine (Hernandez et al., Even though the role of GLP-1 on neuroprotection is well-known and new clinical trials have been started for its repurposing in neuroprotection, the role of GLP-1 on reward systems and its potential clinical use for reward modulation still need further studies

Insulin also enhanced angiogenesis by promoting the expression of vascular endothelial growth factor (VEGF) in cancer cells (Stoeltzing et al., 2003

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[41] Amphetamine also has a slight analgesic effect and can enhance the pain relieving effects of opioids