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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

doi: 10.1111/anu.2013.19.issue-6 75 ZhangH.YangW.LiY.HuL.DaiY.ChenJ.et al

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