The bottom line on side effects: Retatrutide is not dramatically riskier for most people, but it is not a simple lateral move
Constipation Checklist for GLP-1 Patients Fatigue on GLP-1 Therapy: Medication Side Effect or Under-Fueling
GLP-1 medications offer real benefits for weight and blood sugar management but those benefits should not come at the cost of bone density, muscle function, or immune health
Specifically, you might wonder: Can I inject Wegovy above the belly button
Hepatic glucagon increases gluconeogenesis and lipolysis via PKA/CREB activation, stimulates brown adipose tissue thermogenesis, and reduces hepatic triglyceride accumulation
This means standard dietary recommendations during GLP-1 treatment, which are not specifically calibrated for older adults, may be insufficient to protect muscle mass in this group