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10.1172/JCI112855 11

Lipidated peptides incorporate fatty acid chains that can improve membrane permeability and extend circulation time, addressing some traditional limitations of peptide drugs

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102 The outcome is increased water entry into the neurons caused by osmotic lysis and an overabundance of chloride and calcium ions

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You should avoid it if you: Have a history of seizures Have uncontrolled high blood pressure Have a substance use disorder Have a history of eating disorders, such as bulimia or anorexia nervosa Have taken monoamine oxidase inhibitors ( MAOIs ) in the last 14 days Use opioid pain medications Are in the process of discontinuing alcohol, benzodiazepines, barbiturates, and/or anti-seizure medications Are using other forms of bupropion Contrave may not be recommended if you have suicidal thoughts, heart disease, liver issues, or type 2 diabetes (due to a possible risk of low blood sugar)