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But they bought more chewing gum, mouthwash and hair dyes - products that counter common GLP-1 side effects like thinning hair and bad breath

Further, direct stimulation of the GLP-1 receptor on cholangiocytes can lead to enhanced cellular proliferation and an elevated likelihood of cholestasis [47]

GLP-1 exerts its effects through several key mechanisms: Glucose-dependent insulin secretion : GLP-1 stimulates pancreatic beta cells to release insulin, but only when blood glucose levels are elevated, reducing the risk of hypoglycaemia Glucagon suppression : It inhibits the release of glucagon from pancreatic alpha cells, thereby reducing hepatic glucose production Delayed gastric emptying : GLP-1 slows the rate at which food leaves the stomach, leading to more gradual glucose absorption and increased satiety Appetite regulation : Acting on brain centres, GLP-1 promotes feelings of fullness and reduces food intake Prescription GLP-1 receptor agonists (such as semaglutide, dulaglutide, and liraglutide) are synthetic analogues designed to mimic and enhance these natural effects

This practice is used off-label and not supported by any clinical research

All authors contributed to the article and approved the submitted version

On top of that, one of the biggest complaints about GLP-1s, when taken according to the standard doses approved by the FDA is that they cause side effects such as nausea, diarrhea and fatigue