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This is compared to non-pharmacological weight loss involving calorie restriction leading to as much as 30% muscle loss

That doesnt mean were never going to understand why, but it means today, so far, its very difficult, even with very high-powered omics science, to understand this interindividual variation in response.

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The findings at the University of Colorado Anschutz, shared with the Post , were made as researchers studied young women taking GLP-1 medications to treat a common hormonal condition, PCOS, recently renamed to polyendocrine metabolic ovarian syndrome or PMOS

A rigorous LC-MS pharmacokinetic study in rats would provide a definitive reference

Angew Chem Int Ed Engl 43(10):12681270