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Since the intestinotrophic effects of pharmacological GLP-1R and GLP-2R activation both require keratinocyte growth factor (KGF/ Fgf7) 15,34 and pharmacological GLP-2 also requires insulin-like growth factor-1 (IGF) action to increase villus length and small intestinal weight 52 , we measured the mRNA expression of these target genes in response to cold stress

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Additionally, they enhance blood perfusion, microvessel density, and muscle structural integrity in diabetic mice