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Concurrently, improved insulin sensitivity suppresses adipose tissue lipolysis and reduces circulating free fatty acid concentrations [57]
This is particularly important following dose increases
27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity
opt for a short walk instead If youre constipated, eat a wide variety of fibre sources (wholegrains, beans, lentils, fruits, vegetables, nuts, seeds) Inject in the evening if nausea is affecting your day If youve been vomiting for more than 24 hours, contact your clinician Speak to your doctor or prescribing physician if symptoms persist or become too uncomfortable If symptoms havent settled after several weeks at a stable dose, they may not settle on their own so its best to speak with your prescribing clinician or pharmacist
What are GLP-1s
Dipeptidyl peptidase-4 inhibitors DPP-4 is a part of the serine protease family that is found in two membrane-bound and soluble forms in various tissues such as the heart, lung, kidney and liver
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