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Remarkably, the simple parsimonious model of a negative feedback in the GPCR signaling pathway captures the key features that we observed experimentally (Fig 2): An on step of the diacetyl stimulus resulted in a single calcium pulse, which decayed to baseline levels even though the stimulus remained constantly present (Fig 2A)

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Keren-Shaul et al

doi: 10.3390/ijms23105354 102 MaoZ

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