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Recent studies by Sanofi-Aventis and Eli Lilly in phase 1 and 2, respectively, were the first to report and have stimulated further interest in the field

Furthermore, GLP-1 analogs may restore insulin secretion by activating the GLP-1 receptor (GLP-1R)-Gs signals because GLP-1 analogs overcome SSTR5-Gi signals in pancreatic -cells under the condition of suppressed insulin production and spare suppressed incretin secretion from intestinal L-cells 27

A recent review, published by the Journal of the Endocrine Society has concluded that these medications, traditionally prescribed for glycemic control and weight management are emerging as a promising treatment for a variety of additions

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