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One of the key strengths of this study is its integrative approach, combining oxidative stress, inflammatory, genetic, and epigenetic biomarkers with insights from multi-omics technologies and artificial intelligence applications

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Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)

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