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Severe anion gap metabolic acidosis from acetaminophen use secondary to 5-oxoproline (pyroglutamic acid) accumulation

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This leads to ER stress, mitochondrial dysfunction, and ROS accumulation, ultimately impairing cellular function [212, 213]

Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB)

We observed that spleen tissue has cystine content at 1045 M which is even less than in plasma (Supplementary Fig

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