For those who do not achieve glycemic targets with lifestyle therapy, metformin, and SGLT2i, or who cannot tolerate these agents, whether due to adverse events or because other restrictions apply, other medications are recommended
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Serious allergic reaction: swelling of the face, lips, tongue or throat, difficulty breathing or swallowing, severe rash or itching, fainting, or a very rapid heartbeat
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However, stopping the medication often leads to weight regain
Research comparing these approaches head-to-head remains limited, leaving the choice to researcher preference and practical considerations