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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Guan R, Yang Q, Yang X, Du W, Li X, Ma G

Insulin Resistance Certain peptides, particularly those that stimulate IGF-1 or growth hormone (GH) , can increase insulin levels and reduce insulin sensitivity over time

131 Other data indicate that depletion of single amino acids such as methionine is sufficient for hepatic FGF21 production

The same study observed that GLP-1RAs significantly reduced the risk of alcohol abuse by 65% and substance abuse by nearly 50%

GLP-1 receptor agonists have shown strong efficacy in promoting weight loss and improving glycemic control, making them a preferred choice for patients with obesity, type 2 diabetes, and cardiovascular risk factors