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It is used off-label in clinical and aesthetic medicine

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Low doses of methyl donors once the rest of the pathways are better and later maybe some GSH can be tolerated.

Topical makes the most sense for: Facial skin texture, fine lines, hydration Scalp application for localized hair growth Scar treatment or post-procedure recovery on a specific area Patients who want to fold GHK-Cu into an existing skincare routine Injectable makes the most sense for: Systemic wound healing (especially internal or in areas you can't easily apply cream) Joint and connective tissue support (topical simply can't penetrate deep enough) Broader anti-aging goals beyond the skin surface Patients already running other injectable peptide protocols (CJC-1295/ipamorelin, BPC-157, TB-500) Here's the thing: for joints specifically, there's no argument