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Widened QRS 3
The peptide sequence incorporates critical modifications to native human amylin: an N-terminal lipidation with eicosanedioic acid conjugated through a gamma-glutamic acid linker, strategic proline substitutions to prevent fibril formation, and an amidated C-terminus to enhance receptor binding
Nevertheless, the requirement of chylomicron formation for GIP secretion from proximal K cells corresponds to a location-specific stimulus
View at PubMed Cheng K, Chan WW, Barreto A Jr, Convey EM, Smith RG
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The team worked around this by adopting a physical organic chemistry approach to precisely tune the reactivity to distinguish between normal and pathological states
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