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Distribution of the ghrelin receptor In rat tissues, the ghrelin receptor is abundantly expressed in the hypothalamic arcuate nucleus, a key center for feeding regulation ( Although the ghrelin receptor is predominantly expressed in the central nervous system, a broad expression pattern of the gene encoding the ghrelin receptor is observed in various peripheral tissues, including the thyroid, pancreas, spleen, myocardium, adrenal gland, testis, ovary, stomach, and intestinal neurons (Gaytan et al., 2003

doi:10.1360/982005-983

For multiple comparisons between experimental groups and control groups, Dunnetts test was used to check the significant differences

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MOTS-c directly addresses these mechanisms

1h and Extended Data Fig