Eur J Clin Investig 44(12):11591168
Efficacy and safety of retatrutide, a novel GLP-1, GIP, and
The fraction of intact sermorelin that reaches systemic circulation through this route is not consistent across patients, is not validated in controlled clinical trials for adult GH optimization, and is not comparable to what subcutaneous injection achieves in terms of IGF-1 response
Cons Compounded medications are not FDA approved
Ozempic is a brand name for semaglutide, a medication thats FDA-approved to manage blood sugar in people with Type 2 diabetes, and approved for cardiovascular risk reduction and kidney disease
Independent research specifically on transdermal delivery of the botanical compounds in Patchie was limited at the time of this review