The earliest it could hit the market would be late 2026, though it's more likely to drop in 2027
In the Rybelsus trials, gastrointestinal complaints rose with dose: for example, nausea was reported by about 6 percent of people on placebo, 11 percent on the 7 mg tablet, and 20 percent on the 14 mg tablet, and the majority of nausea, vomiting, and diarrhea occurred during dose escalation rather than steady state
Notably, ammonia is simultaneously generated as a byproduct of glutamine deamination
Metabolism 62 , 16511661 (2013)
For all practical purposes, yes
While this type of reaction is common with many subcutaneous injections, some people may be more prone to it because of factors like skin sensitivity or improper injection technique