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To optimize effective absorption, patients are required to adhere to complicated dosing conditions of taking the drug in a fasting state (at least 30 minutes before any food intake) with no more than 4 ounces (approximately 120 mL) of plain water

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Recently, hypoxia-induced expression of the SLC1A5 variant was shown to be mediated by HIF-2 and to lead to metabolic reprogramming toward glutamine metabolism in pancreatic cancer cells 16