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The BELIEVE Phase 2b trial demonstrated that bimagrumab resulted in significant fat loss while preserving lean muscle mass, with participants experiencing an average gain of 2.5% in lean mass

2% WL with placebo in people with obesity [68]

Climacteric 15:317319 Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S (2008) Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial

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This was accompanied by the induction of both white and brown adipocyte markers, alongside the downregulation of anti-adipogenic genes like delta-like 1 homolog ( DLK1 ), forkhead box protein O1 (FOXO1), and Wnt family member 3 A ( WNT3A ) in hMSC [16]

If someone is not a fit for a treatment, that should be said plainly