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Inhibition of either pathway can lead to accumulation of its metabolite, 6-MP, and result in significant bone marrow toxicity

In most cases, symptoms improve as weight stabilizes and the body adapts to its new metabolic state, typically within several months of reaching a stable weight

doi: 10.1097/00001813-200211002-00002 115 BorossPLeusenJH

Researchers at Monash University recognized that many individuals seeking fat loss could not tolerate or did not need growth hormones broader effects including muscle growth, glucose elevation, and IGF-1 stimulation

Reproductive BioMedicine Online, 2006