Total RNA extraction, first-strand cDNA synthesis, and qRT-PCR were performed as described by Wang et al
In resting cells, GHK-Cu produces modest ERK1/2 activation supporting proliferative responses, while in inflammatory conditions, the peptide suppresses p38 and JNK activation, contributing to anti-inflammatory effects
PMID: 41093057 Adv Sci (Weinh) The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice
Translating this paradigm to GLP-1R ligands could enable spatiotemporally gated peptide release or tumor ablation in GLP-1R-rich neuroendocrine cancers
Ann Rheum Dis (2016) 75(6):118795
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