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at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)
too little compromises neurosteroid balance
Because the difference in aMT6s urine concentration in the light and dark phases reflects pineal activity, it has been suggested that an increase in the nighttime production of aMT6s after the first dose of antidepressant medication could work as a fingerprint of the integrity of this system
Neuropharmacology 247 , 109862
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