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24-Wk -alanine ingestion does not affect muscle taurine or clinical blood parameters

This combo provides the internal defense system necessary to counteract those external factors

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The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

Immunobiol 218:116674

Some people notice changes within days to weeks, while others may not notice clear effects