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However, pharmacodynamic interactionswhere drugs alter each other's effects on the bodyare clinically significant

Our data suggest that hypermethylation of the 25-hydroxylases, 1--hydroxylase enzymes, and the vitamin D receptor promoter, accompanied by hypomethylation of CYP24A1, leads to impaired expression and possibly a predisposition to VD deficiency/inadequacy

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However, GLP-1RAs have only been shown to reduce albuminuria, and their ability to reduce progression to ESRD remains to be elucidated