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Group 1 used a placebo, group 2 used oral L-carnitine (2 g/d) + acetyl-L-carnitine (1 g/d), group 3 used L-carnitine/acetyl-L-carnitine + 1 x 30-mg cinnoxicam suppository every 4 days

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Lesser evidence suggests it supplies neuro-protective antioxidant activity, promotes nerve growth factor and boosts brain circulation

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While mechanistic studies suggest that VEs antioxidant properties attenuate lipid peroxidation cascades and mitochondrial dysfunction, emerging evidence positions VE as a pleiotropic regulator, suppressing glutamate excitotoxicity, stabilizing BBB integrity, and tempering IL-1-mediated neuroinflammation (Fig